Efeito do Diazepam sobre a resposta comportamental ao estresse em ratas nulíparas e primíparas

Abstract

The reproductive experience (ER), that is, the set of pregnancy, childbirth and lactation, is associated with changes in hormone secretion, reducing, for example, steroids and prolactin, possibly for the rest of a female's life. It has been shown that responses to stress are related to the behavioral expression of anxiety in the elevated plus-maze, since stress has an anxiogenic effect in this experimental model, and that both responses to stress and anxiety can be permanently modified according to the RE. In addition, it has been previously demonstrated that the sensitivity of primiparous females to stress can be reduced. Thus, this research project aims to continue previous studies in our laboratory about RE and its relationship with anxiety and stress, by studying the behavior of rats in the elevated plus-maze, evaluating the effect of diazepam.