Browsing by Author "VARGAS, Thiago Henrique Moroni"

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Abordagens clinicas e aspectos patológicos relacionados relacionados ao hemangiossarcoma cardíaco em cães: revisão de literatura
(Fundação de Ensino Octávio Bastos, 2023-10-18) TAGLIAFERRO, Karoline Saturnino; VARGAS, Thiago Henrique Moroni
Hemangiosarcoma is characterized by being a malignant neoplasm originating from the mesenchymal tissue of endothelial cells, being an important measurement in dogs, as it manifests itself in several organs, including the heart, in a primary or secondary way (through metastasis). In the heart, this disease can be observed in the walls of the right atrium, and, eventually, in the right ventricle. Cardiac hemangiosarcoma may have clinical signs, mainly cardiac tamponade, right heart failure, pericardial effusion and cardiac arrhythmia, however, such signs may vary according to the size of the tumor. In relation to etiopathogenesis and oncogenesis, they have not yet been well clarified, where their origin indicates that they are from bone marrow precursor endothelial cells, and it is also worth highlighting the association with hereditary predisposition. Furthermore, its diagnosis is difficult to conclude, as the changes are not well visualized in exams, such as radiography, laboratory and cytological analyzes of the pericardial fluid, due to the difficult cell differentiation in the effusion. Therefore, definitive diagnosis includes thoracotomy or thoracoscopy, together with biopsy. Regarding treatment, surgical or chemotherapy methods can be taken, such as performing exploratory thoracotomy to resect the tumor mass, respecting safety margins. While chemotherapy includes the interaction of vincristine, doxorubicin and cyclophosphamide, it is more advisable to administer it immediately after the surgical procedure. Therefore, the aim of this work was to highlight and analyze clinical and pathological aspects of this disease, taking into account literary data related to cardiac hemangiosarcoma in dogs.
Carcinoma de células escamosas em felinos: revisão de literatura
(Fundação de Ensino Octávio Bastos, 2019-09-18) CARRIJO, Jacqueline Ohana Vaz; BIBIANO, Milena; RIBEIRO, Veridiana Pereira Alves; VARGAS, Thiago Henrique Moroni
Cutaneous neoplasms have a high incidence in the clinical routine of small animals, so the in-depth study of this class of tumors is essential. In the feline species, it refers to a predisposition for the appearance of squamous cell carcinoma (SCC), mainly affecting areas of hairy rarefaction, hypopigmented or depigmented. Environmental factors such as ultraviolet radiation, genetic and infectious factors are related to the appearance of this neoplasm, which has an aggressive behavior locally and is very progressive if not diagnosed and treated early. In this way, we highlight the importance of recognizing its most characteristic macroscopic aspects as well as diagnostic tools for early diagnosis and a better prognosis or a better quality of life for animals.
Microambiente tumoral angiogênese
(Fundação de Ensino Octávio Bastos, 2023-10-18) FURLAN, Ana Paula; VARGAS, Thiago Henrique Moroni
The tumor microenvironment is a complex and dynamic environment that involves not only cancer cells, but also a variety of stromal cells, extracellular molecules and blood vessels. Among the many biological processes that occur in the tumor microenvironment, neovascularization, or the formation of new blood vessels, plays a fundamental role in cancer progression. Tumor angiogenesis is regulated by several soluble factors, including vascular endothelial growth factor (VEGF), which is produced by both cancer cells and surrounding stromal cells. These soluble factors stimulate the formation of new blood vessels in the tumor, providing nutrients and oxygen to cancer cells and allowing them to grow and spread to other parts of the body. The study of the tumor microenvironment and Angiogenesis has been the subject of much research, with the aim of developing new cancer therapies that target these biological processes and improve treatment efficacy.